What is 2-AG?

2 min read

What is 2-AG?

Interested in learning more about endocannabinoids? Then let’s check out what 2-AG is and how it works.

2-Arachidonoylglycerol or 2-AG is one of the main endocannabinoids, along with anandamide. 2-AG works by interacting with the CB receptors located in both the central and peripheral nervous systems in our bodies. 2-AG is a full agonist for both CB receptors as well as being the primary binding molecule for the CB2 receptor.

The endocannabinoid system isn’t something you get from consuming cannabis. We all have an endocannabinoid system, and it’s responsible for maintaining balance in our bodies. Cannabinoids and endocannabinoids work by attaching themselves to the receptors located around the endocannabinoid system. When the endocannabinoids and cannabinoids attach themselves to the receptors, there is a chemical reaction. It’s this chemical reaction which produces changes in our bodies. Endocannabinoids and cannabinoids are like the keys which unlock the receptors which are like locks. Cannabinoids are found in the cannabis plant, and endocannabinoids are produced by our bodies.

2-AG is part of the group of molecules which come from arachidonic acid or two other 20-carbon essential fatty acids which are known as a DGLA and EPA. These molecules are known as eicosanoids and are oxidized versions of the essential fatty acids. They play complicated, but important roles in different bodily processes which include inflammation and immunity.

One of the most abundant endocannabinoids found within our bodies, 2-AG plays an important role in the regulation of appetite, pain management, and immune system functions. There are several different ways that you can boost the levels of 2-AG in your body. Cannabis is a great way to help boost and support your endocannabinoid system, but there are also other ways you can help your endocannabinoid system without cannabis.

Below is three different ways that you can boost the levels of 2-AG:

Your Diet 

Because 2-AG is essentially made from fats, or metabolized linoleic acid, you can eat foods high in linoleic acids like eggs, poultry, grains, and hemp seeds. To boost your levels of 2-AG, diets high in omega-6 essential fatty acids is a great way to start. Remember to consume equal amounts of omega-3 and omega-6 fatty acids to get the most benefit to your endocannabinoid system.


Some research suggests that probiotics help to increase the expression of CB2 receptors located in the gut. You can eat pre-biotic foods like leeks, artichoke, onions, and garlic. It also helps to eat a lot of high-fiver greens.


Sleep is an essential ingredient in maintaining your bodies levels of 2-AG and maintaining the balance in your endocannabinoid system. Make sure that you are getting regular amounts of good sleep every day.

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